| Bruce Willis | Korben Dallas | |
| Gary Oldman | Jean-Baptiste Emmanuel Zorg | |
| Milla Jovovich | Leeloo | |
| Ian Holm | Victor Cornelius | |
| Chris Tucker | DJ Ruby Rhod | |
| Luke Perry | Billy | |
| Brion James | General Munro | |
| Tom 'Tiny' Lister Jr. | President Lindberg | |
| Lee Evans | Fog | |
| Tricky | Right Arm | |
| Charlie Creed-Miles | David | |
| John Neville | General Staedert | |
| John Bluthal | Professor Pacoli | |
| Mathieu Kassovitz | Mugger | |
| Maïwenn Le Besco | Diva Plava Laguna | |
| Christopher Fairbank | Mactilburgh | |
| Kim Chan | Thai | |
| Richard Leaf | Neighbour | |
| Julie T. Wallace | Major Iceborg | |
| Al Matthews | General Tudor | |
| John Bennett | Priest | |
| Ivan Heng | Left Arm | |
| Sonita Henry | President's Aide | |
| Tim McMullan | Scientist's Aide | |
| Hon Ping Tang | Munro's Captain | |
| George Khan | Head Scientist | |
| John Hughes (VI) | Head of Military | |
| Robert Bryce | Omar | |
| Said Talidi | Aziz | |
| Justin Lee Burrows | Mondoshawan | |
| Richard Ashton | Mondoshawan | |
| Jerome Blake | Mondoshawan | |
| Kevin Molloy | Mondoshawan | |
| Bill Reimbold | Mactilburgh's Assistant | |
| Colin Brooks | Staedert's Captain | |
| Anthony Chinn | Mactilburgh's Technician | |
| Sam Douglas | Chief New York Cop | |
| Derek Ezenagu | New York Cop | |
| David Kennedy | Flying Cop | |
| David Barrass | Flying Cop | |
| Roger Monk (II) | Flying Cop | |
| Mac McDonald | Flying Cop | |
| Jean-Luc Caron | Flying Cop | |
| Riz Meedin | Flying Cop | |
| Jerry Ezekiel | Flying Cop | |
| Martin McDougall | Warship Captain | |
| Peter Dunwell | Diva's Manager | |
| Paul Priestley | Cop | |
| Jason Salkey | Cop | |
| Stewart Harvey-Wilson | Ruby Rohd Assistant | |
| David Fishley | Ruby Rohd Assistant | |
| Carlton Chance | Ruby Rohd Assistant | |
| Vladimir McCrary | Human Aknot | |
| Clifton Lloyd Bryan | Human Aknot/Airport Guard | |
| Aron Paramor | Mangalore Akanit | |
| Alan Ruscoe | Mangalore Kino | |
| Christopher Adamson | Airport Cop | |
| Kaleem Janjua | Shuttle Pilot | |
| Tyrone Tyrell | Shuttle Co-Pilot | |
| Kevin Brewerton | Shuttle Mechanic | |
| Vince Pellegrino | Ground Crew | |
| Ian Beckett | Baby Ray | |
| Sonny Caldinez | Emperor Kodar Japhet | |
| Eddie Ellwood | Roy von Bacon | |
| Michael Culkin | Hefty Man | |
| Lenny McLean | Police Chief | |
| Robert Oates | Fhloston Commander | |
| John Sharian | Fhloston Captain | |
| Grant James | Scientist | |
| Ali Yassissine | Scientist | |
| Sean Buckley | Scientist | |
| Dane Messam | Military Technician | |
| Nathan Hamlett | Military Technician | |
| Cecil Cheng | Military Technician | |
| Scott Woods | Lab Guard | |
| Leon Dekker | Lab Guard | |
| David Garvey | Staedert's Technician | |
| Stanley Kowalski | Staedert's Technician | |
| Omar Williams | Staedert's Technician | |
| Robert Clapperton | Robot Barman | |
| Robert Alexander (I) | Warship Technician | |
| Leo Williams | Power Operator | |
| C. Keith Martin | Power Operator | |
| J.D. Dawodu | Zorg's Man | |
| Patrick Nicholls | Zorg's Man | |
| Shaun Davis | Zorg's Man | |
| Roy Garcia Singh | Zorg's Man | |
| Alex Georgijev | Zorg's Man | |
| Inva Mulla Tchako | Diva (voice) |